| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
BIK |
| Gene ID: |
638 |
| Uniprot ID: |
BIK_HUMAN |
| Immunogen Region: |
1-130 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human BIK (NP_001188.1). |
| Immunogen Sequence: |
MSEVRPLSRDILMETLLYEQ LLEPPTMEVLGMTDSEEDLD PMEDFDSLECMEGSDALALR LACIGDEMDVSLRAPRLAQL SEVAMHSLGLAFIYDQTEDI RDVLRSFMDGFTTLKENIMR FWRSPNPGSW |
| Post Translational Modifications | Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage is a necessary step prior its degradation by the proteosome-dependent mechanism. Ubiquitinated by the ECS(ASB11) complex in response to endoplasmic reticulum stress, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome. |
| Function | Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX. |
| Protein Name | Bcl-2-Interacting KillerApoptosis Inducer NbkBip1Bp4 |
| Cellular Localisation | Endomembrane SystemSingle-Pass Membrane ProteinMitochondrion MembraneAround The Nuclear EnvelopeAnd In Cytoplasmic Membranes |
| Alternative Antibody Names | Anti-Bcl-2-Interacting Killer antibodyAnti-Apoptosis Inducer Nbk antibodyAnti-Bip1 antibodyAnti-Bp4 antibodyAnti-BIK antibodyAnti-NBK antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
