Western blot analysis of lysates from Raji cells, using BIK Rabbit pAb (STJ11107023). <br/>Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. <br/>Lysates/proteins: 25 Mu g per lane. <br/>Blocking buffer: 3% nonfat dry milk in TBST.

Anti-BIK antibody (1-130 aa) (STJ11107023)

SKU:
STJ11107023
£112.50 - £524.50
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Gene Symbol: BIK
Gene ID: 638
Uniprot ID: BIK_HUMAN
Immunogen Region: 1-130 aa
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human BIK (NP_001188.1).
Immunogen Sequence: MSEVRPLSRDILMETLLYEQ LLEPPTMEVLGMTDSEEDLD PMEDFDSLECMEGSDALALR LACIGDEMDVSLRAPRLAQL SEVAMHSLGLAFIYDQTEDI RDVLRSFMDGFTTLKENIMR FWRSPNPGSW
Post Translational Modifications Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage is a necessary step prior its degradation by the proteosome-dependent mechanism. Ubiquitinated by the ECS(ASB11) complex in response to endoplasmic reticulum stress, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome.
Function Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX.
Protein Name Bcl-2-Interacting Killer
Apoptosis Inducer Nbk
Bip1
Bp4
Cellular Localisation Endomembrane System
Single-Pass Membrane Protein
Mitochondrion Membrane
Around The Nuclear Envelope
And In Cytoplasmic Membranes
Alternative Antibody Names Anti-Bcl-2-Interacting Killer antibody
Anti-Apoptosis Inducer Nbk antibody
Anti-Bip1 antibody
Anti-Bp4 antibody
Anti-BIK antibody
Anti-NBK antibody

Information sourced from Uniprot.org

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