| Host: | Mouse |
| Applications: | IF/WB/IHC |
| Reactivity: | Human/Rat/Mouse/Monkey/Dog/Chicken/Hamster/Rabbit/Insect/Pig/Lenok |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Actin, cytoplasmic 1 is suitable for use in Immunofluorescence, Western Blot and Immunohistochemistry research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 5B7 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | Liquid in PBS pH7.4, 0.5% BSA, 0.02% Sodium Azide and 50% Glycerol. |
| Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IF 1:50-200 WB 1:5000-20000 IHC 1:200-300 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ACTB |
| Gene ID: | 60 |
| Uniprot ID: | ACTB_HUMAN |
| Specificity: | The antibody detects endogenous Beta-actin protein. |
| Immunogen: | Synthetic Peptide of Beta-actin |
| Function | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules. |
| Protein Name | Actin - Cytoplasmic 1 Beta-Actin Cleaved Into - Actin - Cytoplasmic 1 - N-Terminally Processed |
| Database Links | Reactome: R-HSA-1445148 Reactome: R-HSA-190873 Reactome: R-HSA-196025 Reactome: R-HSA-2029482 Reactome: R-HSA-3214847 Reactome: R-HSA-389957 Reactome: R-HSA-390450 Reactome: R-HSA-3928662 Reactome: R-HSA-3928665 Reactome: R-HSA-418990 Reactome: R-HSA-437239 Reactome: R-HSA-4420097 Reactome: R-HSA-445095 Reactome: R-HSA-446353 Reactome: R-HSA-5250924 Reactome: R-HSA-5626467 Reactome: R-HSA-5663213 Reactome: R-HSA-5663220 Reactome: R-HSA-5674135 Reactome: R-HSA-5689603 Reactome: R-HSA-5696394 Reactome: R-HSA-6802946 Reactome: R-HSA-6802948 Reactome: R-HSA-6802952 Reactome: R-HSA-6802955 Reactome: R-HSA-8856828 Reactome: R-HSA-9035034 Reactome: R-HSA-9649948 Reactome: R-HSA-9656223 Reactome: R-HSA-9662360 Reactome: R-HSA-9662361 Reactome: R-HSA-9664422 Reactome: R-HSA-9824585 Reactome: R-HSA-983231 Reactome: R-HSA-9845323 |
| Cellular Localisation | Cytoplasm Cytoskeleton Nucleus Localized In Cytoplasmic Mrnp Granules Containing Untranslated Mrnas |
| Alternative Antibody Names | Anti-Actin - Cytoplasmic 1 antibody Anti-Beta-Actin Cleaved Into - Actin - Cytoplasmic 1 - N-Terminally Processed antibody Anti-ACTB antibody |
Information sourced from Uniprot.org