| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-BCO2 (170-410) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BCO2 |
| Gene ID: |
83875 |
| Uniprot ID: |
BCDO2_HUMAN |
| Immunogen Region: |
170-410 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 170-410 of human BCO2 (NP_001243327.1). |
| Immunogen Sequence: |
KAAGFSYKVIRVPPEKVDLG ETIHGVQVICSIASTEKGKP SYYHSFGMTRNYIIFIEQPL KMNLWKIATSKIRGKAFSDG ISWEPQCNTRFHVVEKRTGQ LLPGRYYSKPFVTFHQINAF EDQGCVIIDLCCQDNGRTLE VYQLQNLRKAGEGLDQVHNS AAKSFPRRFVLPLNVSLNAP EGDNLSPLSYTSASAVKQAD GTIWCSHENLHQEDLEKEGG IEFPQIYYDRFSGKKYHFF |
| Tissue Specificity | Highly expressed in retinal pigment epithelium. Also expressed in stomach, small intestine, liver, testis, kidney, adrenal gland, pancreas, heart, skeletal muscle and prostate (at protein level). |
| Function | Broad specificity mitochondrial dioxygenase that mediates the asymmetric oxidative cleavage of carotenoids. Cleaves carotenes (pure hydrocarbon carotenoids) such as all-trans-beta-carotene and lycopene as well as xanthophylls (oxygenated carotenoids) such as zeaxanthin, lutein and beta-cryptoxanthin at both the 9,10 and the 9',10' carbon-carbon double bond. Through its function in carotenoids metabolism regulates oxidative stress and the production of important signaling molecules. |
| Protein Name | Carotenoid-Cleaving Dioxygenase - MitochondrialB-Diox-IiBeta -Beta-Carotene 9' -10'-OxygenaseBeta-Carotene Dioxygenase 2 |
| Database Links | Reactome: R-HSA-975634 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Carotenoid-Cleaving Dioxygenase - Mitochondrial antibodyAnti-B-Diox-Ii antibodyAnti-Beta -Beta-Carotene 9' -10'-Oxygenase antibodyAnti-Beta-Carotene Dioxygenase 2 antibodyAnti-BCO2 antibodyAnti-BCDO2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
