| Tissue Specificity | Highly expressed in retinal pigment epithelium. Also expressed in stomach, small intestine, liver, testis, kidney, adrenal gland, pancreas, heart, skeletal muscle and prostate (at protein level). |
| Function | Broad specificity mitochondrial dioxygenase that mediates the asymmetric oxidative cleavage of carotenoids. Cleaves carotenes (pure hydrocarbon carotenoids) such as all-trans-beta-carotene and lycopene as well as xanthophylls (oxygenated carotenoids) such as zeaxanthin, lutein and beta-cryptoxanthin at both the 9,10 and the 9',10' carbon-carbon double bond. Through its function in carotenoids metabolism regulates oxidative stress and the production of important signaling molecules. |
| Protein Name | Carotenoid-Cleaving Dioxygenase - MitochondrialB-Diox-IiBeta -Beta-Carotene 9' -10'-OxygenaseBeta-Carotene Dioxygenase 2 |
| Database Links | Reactome: R-HSA-975634 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Carotenoid-Cleaving Dioxygenase - Mitochondrial antibodyAnti-B-Diox-Ii antibodyAnti-Beta -Beta-Carotene 9' -10'-Oxygenase antibodyAnti-Beta-Carotene Dioxygenase 2 antibodyAnti-BCO2 antibodyAnti-BCDO2 antibody |
Information sourced from Uniprot.org
