Anti-BAX antibody (80-129 aa) (STJ91820)

SKU:
STJ91820
£48.00 - £252.00
Processing The item has been added

Host: Rabbit
Applications: IHC/IF/WB/ELISA
Reactivity: Human/Mouse/Rat/Chicken
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-Apoptosis regulator BAX (80-129 aa) is suitable for use in Immunohistochemistry, Immunofluorescence, Western Blot and ELISA research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC-P 1:100-300
ELISA 1:20000
IF 1:100-300
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: BAX
Gene ID: 581
Uniprot ID: BAX_HUMAN
Immunogen Region: 80-129 aa
Specificity: Bax Polyclonal Antibody detects endogenous levels of Bax protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human BAX at the amino acid range 80-129
Post Translational Modifications Ubiquitinated on Lys-128 and Lys-190. 'Lys-63'-linked polyubiquitin chains on Lys-128 are removed by USP12.
Function Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
Protein Name Apoptosis Regulator Bax
Bcl-2-Like Protein 4
Bcl2-L-4
Database Links Reactome: R-HSA-111457
Reactome: R-HSA-114294
Reactome: R-HSA-5620971
Reactome: R-HSA-6803204
Reactome: R-HSA-6804114
Reactome: R-HSA-8878166
Reactome: R-HSA-9603505
Cellular Localisation Isoform Alpha: Mitochondrion Outer Membrane
Single-Pass Membrane Protein
Cytoplasm
Nucleus
Colocalizes With 14-3-3 Proteins In The Cytoplasm
Under Stress Conditions
Undergoes A Conformation Change That Causes Release From Jnk-Phosphorylated 14-3-3 Proteins And Translocation To The Mitochondrion Membrane
Upon Sendai Virus Infection
Recruited To The Mitochondrion Through Interaction With Irf3
Isoform Beta: Cytoplasm
Isoform Gamma: Cytoplasm
Isoform Delta: Cytoplasm
Alternative Antibody Names Anti-Apoptosis Regulator Bax antibody
Anti-Bcl-2-Like Protein 4 antibody
Anti-Bcl2-L-4 antibody
Anti-BAX antibody
Anti-BCL2L4 antibody

Information sourced from Uniprot.org