| Tissue Specificity | Ubiquitous (but weakly expressed in all tissues examined). |
| Post Translational Modifications | N-glycosylated. |
| Function | Glycosaminoglycans biosynthesis. Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins. Shows strict specificity for Gal-beta-1,3-Gal-beta-1,4-Xyl, exhibiting negligible incorporation into other galactoside substrates including Galbeta1-3Gal beta1-O-benzyl, Galbeta1-4GlcNAc and Galbeta1-4Glc. Stimulates 2-phosphoxylose phosphatase activity of PXYLP1 in presence of uridine diphosphate-glucuronic acid (UDP-GlcUA) during completion of linkage region formation. |
| Protein Name | Galactosylgalactosylxylosylprotein 3-Beta-Glucuronosyltransferase 3Beta-1 -3-Glucuronyltransferase 3Glucuronosyltransferase IGlcat-IUdp-Glcua -Gal Beta-1 -3-Gal-R GlucuronyltransferaseGlcuat-I |
| Database Links | Reactome: R-HSA-1971475Reactome: R-HSA-3560801 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane ProteinGolgi ApparatusCis-Golgi Network |
| Alternative Antibody Names | Anti-Galactosylgalactosylxylosylprotein 3-Beta-Glucuronosyltransferase 3 antibodyAnti-Beta-1 -3-Glucuronyltransferase 3 antibodyAnti-Glucuronosyltransferase I antibodyAnti-Glcat-I antibodyAnti-Udp-Glcua -Gal Beta-1 -3-Gal-R Glucuronyltransferase antibodyAnti-Glcuat-I antibodyAnti-B3GAT3 antibody |
Information sourced from Uniprot.org
