| Tissue Specificity | Expressed in adult and fetal kidney. Found in the inner ear. |
| Function | Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Involved in normal vectorial acid transport into the urine by the kidney. |
| Protein Name | V-Type Proton Atpase 116 Kda Subunit A 4V-Atpase 116 Kda Isoform A 4Vacuolar Proton Translocating Atpase 116 Kda Subunit A Isoform 4Vacuolar Proton Translocating Atpase 116 Kda Subunit A Kidney Isoform |
| Database Links | Reactome: R-HSA-1222556Reactome: R-HSA-77387Reactome: R-HSA-917977Reactome: R-HSA-983712 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneLocalizes To The Apical Surface Of Alpha-Intercalated Cells In The Cortical Collecting Ducts Of The Distal NephronLocalizes To The Basolateral Surface Of Beta-Intercalated Cells In The Cortical Collecting Ducts Of The Distal Nephron |
| Alternative Antibody Names | Anti-V-Type Proton Atpase 116 Kda Subunit A 4 antibodyAnti-V-Atpase 116 Kda Isoform A 4 antibodyAnti-Vacuolar Proton Translocating Atpase 116 Kda Subunit A Isoform 4 antibodyAnti-Vacuolar Proton Translocating Atpase 116 Kda Subunit A Kidney Isoform antibodyAnti-ATP6V0A4 antibodyAnti-ATP6N1B antibodyAnti-ATP6N2 antibody |
Information sourced from Uniprot.org
