Host: |
Rabbit |
Applications: |
WB/IHC-P/IF/ICC/ELISA |
Reactivity: |
Human/Mouse/Rat |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
Purification: |
Affinity purification |
Concentration: |
Lot specific |
Dilution Range: |
WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
ANTXR2 |
Gene ID: |
118429 |
Uniprot ID: |
ANTR2_HUMAN |
Immunogen Region: |
34-300 |
Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 34-300 of human ANTXR2 (NP_001139266.1). |
Immunogen Sequence: |
QEQPSCRRAFDLYFVLDKSG SVANNWIEIYNFVQQLAERF VSPEMRLSFIVFSSQATIIL PLTGDRGKISKGLEDLKRVS PVGETYIHEGLKLANEQIQK AGGLKTSSIIIALTDGKLDG LVPSYAEKEAKISRSLGASV YCVGVLDFEQAQLERIADSK EQVFPVKGGFQALKGIINSI LAQSCTEILELQPSSVCVGE EFQIVLSGRGFMLGSRNGSV LCTYTVNETYTTSVKPVSV |
Tissue Specificity | Expressed in prostate, thymus, ovary, testis, pancreas, colon, heart, kidney, lung, liver, peripheral blood leukocytes, placenta, skeletal muscle, small intestine and spleen. |
Function | Necessary for cellular interactions with laminin and the extracellular matrix. (Microbial infection) Receptor for the protective antigen (PA) of B.anthracis. Binding of PA leads to heptamerization of the receptor-PA complex. Upon binding of the PA of B.anthracis, the complex moves to glycosphingolipid-rich lipid rafts, where it is internalized via a clathrin-dependent pathway. In the endosomal membrane, at pH under 7, the complex then rearranges and forms a pore allowing the other components of anthrax toxin to escape to the cytoplasm. |
Protein Name | Anthrax Toxin Receptor 2Capillary Morphogenesis Gene 2 ProteinCmg-2 |
Database Links | Reactome: R-HSA-5210891 |
Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinExpressed At The Cell SurfaceIsoform 2: Endoplasmic Reticulum MembraneExpressed Predominantly Within The Endoplasmic Reticulum And Not At The Plasma MembraneIsoform 3: Secreted |
Alternative Antibody Names | Anti-Anthrax Toxin Receptor 2 antibodyAnti-Capillary Morphogenesis Gene 2 Protein antibodyAnti-Cmg-2 antibodyAnti-ANTXR2 antibodyAnti-CMG2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance