| Tissue Specificity | Highly expressed in marrow from patients with pre-B ALL associated with the t(1.9) translocation. Strongly expressed in brain and testis. Expressed in fetal brain. Isoform 4 is highly expressed in brain (at protein level). Isoform 6 is expressed in brain and several cancer cell lines. |
| Post Translational Modifications | Isoform 3 nuclear translocation requires an NMDAR-dependent proteolytic cleavage. |
| Function | Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells. Isoform 3 can regulate global protein synthesis by altering nucleolar numbers. Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing. |
| Protein Name | Ankyrin Repeat And Sterile Alpha Motif Domain-Containing Protein 1bAmyloid-Beta Protein Intracellular Domain-Associated Protein 1Aida-1E2a-Pbx1-Associated ProteinEb-1 |
| Cellular Localisation | CytoplasmIsoform 2: NucleusIsoform 3: Postsynaptic DensityCell ProjectionDendritic SpineNucleusCajal BodyThe Synaptic Localization Requires Dlg4 InteractionTranslocation To The Nucleus In Response To Stimulation Of Nmda Receptors (Nmdars) In A Calcium-Independent MannerIsoform 4: NucleusThe Interaction With App Causes Its Partial Exclusion From The NucleusWhen App Is OverexpressedIsoform 6: Nucleus |
| Alternative Antibody Names | Anti-Ankyrin Repeat And Sterile Alpha Motif Domain-Containing Protein 1b antibodyAnti-Amyloid-Beta Protein Intracellular Domain-Associated Protein 1 antibodyAnti-Aida-1 antibodyAnti-E2a-Pbx1-Associated Protein antibodyAnti-Eb-1 antibodyAnti-ANKS1B antibody |
Information sourced from Uniprot.org
