| Function | Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase. |
| Protein Name | A-Kinase Anchor Protein 10 - MitochondrialAkap-10Dual Specificity A Kinase-Anchoring Protein 2D-Akap-2Protein Kinase A-Anchoring Protein 10Prka10 |
| Database Links | Reactome: R-HSA-983231 |
| Cellular Localisation | MitochondrionMembraneCytoplasmPredominantly Mitochondrial But Also Membrane Associated And Cytoplasmic |
| Alternative Antibody Names | Anti-A-Kinase Anchor Protein 10 - Mitochondrial antibodyAnti-Akap-10 antibodyAnti-Dual Specificity A Kinase-Anchoring Protein 2 antibodyAnti-D-Akap-2 antibodyAnti-Protein Kinase A-Anchoring Protein 10 antibodyAnti-Prka10 antibodyAnti-AKAP10 antibody |
Information sourced from Uniprot.org
