| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ADNP |
| Gene ID: | 23394 |
| Uniprot ID: | ADNP_HUMAN |
| Immunogen Region: | 843-1102 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 843-1102 of human ADNP (NP_056154.1). |
| Immunogen Sequence: | EWLFENHDEKDSRVNASKTA DKKLNLGKEDDSSSDSFENL EEESNESGSPFDPVFEVEPK ISNDNPEEHVLKVIPEDASE SEEKLDQKEDGSKYETIHLT EEPTKLMHNASDSEVDQDDV VEWKDGASPSESGPGSQQVS DFEDNTCEMKPGTWSDESSQ SEDARSSKPAAKKKATMQGD REQLKWKNSSYGKVEGFWSK DQSQWKNASENDERLSNPQI EWQNSTIDSEDGEQFDNMT |
| Tissue Specificity | Widely expressed. Strong expression in heart, skeletal muscle, kidney and placenta. In brain, expression is stronger in the cerebellum and cortex regions. No expression detected in the colon. Strong increase of expression in colon and breast cancer tissues. |
| Function | May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation. |
| Protein Name | Activity-Dependent Neuroprotector Homeobox ProteinActivity-Dependent Neuroprotective Protein |
| Cellular Localisation | NucleusChromosome |
| Alternative Antibody Names | Anti-Activity-Dependent Neuroprotector Homeobox Protein antibodyAnti-Activity-Dependent Neuroprotective Protein antibodyAnti-ADNP antibodyAnti-ADNP1 antibodyAnti-KIAA0784 antibody |
Information sourced from Uniprot.org