Anti-ADAMTS5 nanobody [SAA1219] (STJN000314)

SKU:
STJN000314
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Host: Alpaca
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Alpaca monoclonal nanobody anti-A Disintegrin And Metalloproteinase With Thrombospondin Motifs 5 is suitable for use in ELISA research applications.
Clonality : Monoclonal
Clone ID : SAA1219
Conjugation: Unconjugated
Isotype: VHH-8His-Cys-tag
Formulation: 0.01M PBS, pH 7.4.
Purification: Purified by Nickel column.
Concentration: 1 mg/mL
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term.
Gene Symbol: ADAMTS5
Gene ID: 11096
Uniprot ID: ATS5_HUMAN
Post Translational Modifications The precursor is cleaved by furin and PCSK7 outside of the cell. Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion.
Function Metalloproteinase that plays an important role in connective tissue organization, development, inflammation and cell migration. Extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including ACAN, VCAN, BCAN and NCAN. Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its VCAN remodeling properties. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration. Participates in development of brown adipose tissue and browning of white adipose tissue. Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection.
Protein Name A Disintegrin And Metalloproteinase With Thrombospondin Motifs 5
Adam-Ts 5
Adam-Ts5
Adamts-5
A Disintegrin And Metalloproteinase With Thrombospondin Motifs 11
Adam-Ts 11
Adamts-11
Admp-2
Aggrecanase-2
Database Links Reactome: R-HSA-1474228
Reactome: R-HSA-5083635
Reactome: R-HSA-5173214
Cellular Localisation Secreted
Extracellular Space
Extracellular Matrix
Alternative Nanobody Names Anti-A Disintegrin And Metalloproteinase With Thrombospondin Motifs 5 nanobody
Anti-Adam-Ts 5 nanobody
Anti-Adam-Ts5 nanobody
Anti-Adamts-5 nanobody
Anti-A Disintegrin And Metalloproteinase With Thrombospondin Motifs 11 nanobody
Anti-Adam-Ts 11 nanobody
Anti-Adamts-11 nanobody
Anti-Admp-2 nanobody
Anti-Aggrecanase-2 nanobody
Anti-ADAMTS5 nanobody
Anti-ADAMTS11 nanobody
Anti-ADMP2 nanobody

Information sourced from Uniprot.org