| Post Translational Modifications | The Ser/Thr residues in the C-terminal cytoplasmic tail may be phosphorylated. |
| Function | Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus. |
| Protein Name | Atypical Chemokine Receptor 4C-C Chemokine Receptor Type 11C-C Ckr-11Cc-Ckr-11Ccr-11Cc Chemokine Receptor-Like 1Ccrl1Ccx Ckr |
| Database Links | Reactome: R-HSA-380108 |
| Cellular Localisation | Early EndosomeRecycling EndosomeCell MembraneMulti-Pass Membrane ProteinPredominantly Localizes To Endocytic VesiclesAnd Upon Stimulation By The Ligand Is Internalized Via CaveolaeOnce InternalizedThe Ligand Dissociates From The ReceptorAnd Is Targeted To Degradation While The Receptor Is Recycled Back To The Cell Membrane |
| Alternative Antibody Names | Anti-Atypical Chemokine Receptor 4 antibodyAnti-C-C Chemokine Receptor Type 11 antibodyAnti-C-C Ckr-11 antibodyAnti-Cc-Ckr-11 antibodyAnti-Ccr-11 antibodyAnti-Cc Chemokine Receptor-Like 1 antibodyAnti-Ccrl1 antibodyAnti-Ccx Ckr antibodyAnti-ACKR4 antibodyAnti-CCBP2 antibodyAnti-CCR11 antibodyAnti-CCRL1 antibodyAnti-VSHK1 antibody |
Information sourced from Uniprot.org
