| Function | Endoplasmic reticulum and Golgi ceramidase that catalyzes the hydrolysis of unsaturated long-chain C18:1-, C20:1- and C20:4-ceramides, dihydroceramides and phytoceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Controls the generation of sphingosine in erythrocytes, and thereby sphingosine-1-phosphate in plasma. Through the regulation of ceramides and sphingosine-1-phosphate homeostasis in the brain may play a role in neurons survival and function. By regulating the levels of pro-inflammatory ceramides in immune cells and tissues, may modulate the inflammatory response. |
| Protein Name | Alkaline Ceramidase 3Alkcdase 3Alkaline Cdase 3Alkaline Dihydroceramidase Sb89Alkaline PhytoceramidaseAphc |
| Database Links | Reactome: R-HSA-9845614 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi Apparatus Membrane |
| Alternative Antibody Names | Anti-Alkaline Ceramidase 3 antibodyAnti-Alkcdase 3 antibodyAnti-Alkaline Cdase 3 antibodyAnti-Alkaline Dihydroceramidase Sb89 antibodyAnti-Alkaline Phytoceramidase antibodyAnti-Aphc antibodyAnti-ACER3 antibodyAnti-APHC antibodyAnti-PHCA antibody |
Information sourced from Uniprot.org
