• Western blot analysis of lysates from Jurkat cells, using ABCD1 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of the lysates from HeLa cells using ABCD1 antibody.
  • Western blot analysis of Hela cells using ABCD1 Polyclonal Antibody

Anti-ABCD1 antibody (500-580 Internal) (STJ91414)

SKU:
STJ91414

Current Stock:
Host: Rabbit
Applications: WB, ELISA
Reactivity: Human, Rat, Mouse
Note: FOR RESEARCH USE ONLY (RUO).
Short Description: Rabbit polyclonal antibody anti-Atp-Binding Cassette Sub-Family D Member 1 (500-580 Internal) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS, 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit anti-serum by affinity-chromatography.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
ELISA 1:40000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ABCD1
Gene ID: 215
Uniprot ID: ABCD1_HUMAN
Immunogen Region: 500-580 Internal
Specificity: ABCD1 polyclonal antibody (Atp-Binding Cassette Sub-Family D Member 1) binds to endogenous Atp-Binding Cassette Sub-Family D Member 1 at the amino acid region 500-580 Internal.
Immunogen: The antiserum was produced against synthesized peptide derived from human ABCD1 at amino acid range 531-580
Function ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen. Coupled to the ATP-dependent transporter activity has also a fatty acyl-CoA thioesterase activity (ACOT) and hydrolyzes VLCFA-CoA into VLCFA prior their ATP-dependent transport into peroxisomes, the ACOT activity is essential during this transport process. Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation. Involved in several processes.namely, controls the active myelination phase by negatively regulating the microsomal fatty acid elongation activity and may also play a role in axon and myelin maintenance. Controls also the cellular response to oxidative stress by regulating mitochondrial functions such as mitochondrial oxidative phosphorylation and depolarization. And finally controls the inflammatory response by positively regulating peroxisomal beta-oxidation of VLCFAs.
Protein Name Atp-Binding Cassette Sub-Family D Member 1
Adrenoleukodystrophy Protein
Aldp
Database Links Reactome: R-HSA-1369062
Reactome: R-HSA-2046105
Reactome: R-HSA-2046106
Reactome: R-HSA-390247
Reactome: R-HSA-5684045
Reactome: R-HSA-9603798
Cellular Localisation Peroxisome Membrane
Multi-Pass Membrane Protein
Mitochondrion Membrane
Lysosome Membrane
Endoplasmic Reticulum Membrane
Alternative Antibody Names Anti-Atp-Binding Cassette Sub-Family D Member 1 antibody
Anti-Adrenoleukodystrophy Protein antibody
Anti-Aldp antibody
Anti-ABCD1 antibody
Anti-ALD antibody

Information sourced from Uniprot.org

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