||Human, Rat, Mouse
||FOR RESEARCH USE ONLY (RUO).
||Rabbit polyclonal antibody anti-Atp-Binding Cassette Sub-Family D Member 1 (500-580 Internal) is suitable for use in Western Blot and ELISA research applications.
||PBS, 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
||The antibody was affinity-purified from rabbit anti-serum by affinity-chromatography.
||WB 1:500-1:2000ELISA 1:40000
||Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
||ABCD1 polyclonal antibody (Atp-Binding Cassette Sub-Family D Member 1) binds to endogenous Atp-Binding Cassette Sub-Family D Member 1 at the amino acid region 500-580 Internal.
||The antiserum was produced against synthesized peptide derived from human ABCD1 at amino acid range 531-580
| Function || ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen. Coupled to the ATP-dependent transporter activity has also a fatty acyl-CoA thioesterase activity (ACOT) and hydrolyzes VLCFA-CoA into VLCFA prior their ATP-dependent transport into peroxisomes, the ACOT activity is essential during this transport process. Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation. Involved in several processes.namely, controls the active myelination phase by negatively regulating the microsomal fatty acid elongation activity and may also play a role in axon and myelin maintenance. Controls also the cellular response to oxidative stress by regulating mitochondrial functions such as mitochondrial oxidative phosphorylation and depolarization. And finally controls the inflammatory response by positively regulating peroxisomal beta-oxidation of VLCFAs. |
| Protein Name || Atp-Binding Cassette Sub-Family D Member 1Adrenoleukodystrophy ProteinAldp |
| Database Links || Reactome: R-HSA-1369062Reactome: R-HSA-2046105Reactome: R-HSA-2046106Reactome: R-HSA-390247Reactome: R-HSA-5684045Reactome: R-HSA-9603798 |
| Cellular Localisation || Peroxisome MembraneMulti-Pass Membrane ProteinMitochondrion MembraneLysosome MembraneEndoplasmic Reticulum Membrane |
| Alternative Antibody Names || Anti-Atp-Binding Cassette Sub-Family D Member 1 antibodyAnti-Adrenoleukodystrophy Protein antibodyAnti-Aldp antibodyAnti-ABCD1 antibodyAnti-ALD antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance