Anti-ABCC5 antibody (470-550) (STJ190990)


Current Stock:
Host: Rabbit
Applications: WB, ELISA
Reactivity: Human, Mouse
Short Description: Rabbit polyclonal antibody anti-Atp-Binding Cassette Sub-Family C Member 5 (470-550) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS, 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit anti-serum by affinity-chromatography.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ABCC5
Gene ID: 10057
Uniprot ID: MRP5_HUMAN
Immunogen Region: 470-550
Specificity: ABCC5 polyclonal antibody (Atp-Binding Cassette Sub-Family C Member 5) binds to endogenous Atp-Binding Cassette Sub-Family C Member 5 at the amino acid region 470-550.
Immunogen: Synthesized peptide derived from human protein at aa range 470-550
Function ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of endogenous metabolites such as cAMP and cGMP, folic acid and N-lactoyl-amino acids (in vitro). Acts also as a general glutamate conjugate and analog transporter that can limit the brain levels of endogenous metabolites, drugs, and toxins. Confers resistance to the antiviral agent PMEA. Able to transport several anticancer drugs including methotrexate, and nucleotide analogs in vitro, however it does with low affinity, thus the exact role of ABCC5 in mediating resistance still needs to be elucidated. Acts as a heme transporter required for the translocation of cytosolic heme to the secretory pathway. May play a role in energy metabolism by regulating the glucagon-like peptide 1 (GLP-1) secretion from enteroendocrine cells.
Protein Name Atp-Binding Cassette Sub-Family C Member 5
Multi-Specific Organic Anion Transporter C
Multidrug Resistance-Associated Protein 5
Database Links Reactome: R-HSA-2142850
Reactome: R-HSA-382556
Cellular Localisation Basolateral Cell Membrane
Multi-Pass Membrane Protein
Golgi Apparatus Lumen
Endosome Membrane
Cytoplasmic Granule
Apical Cell Membrane
In Most Cells
Routes To The Basolateral Plasma Membrane
But In The Brain Capillary Endothelial Cells That Form The Blood-Brain Barrier
Resides In The Apical Membrane
Alternative Antibody Names Anti-Atp-Binding Cassette Sub-Family C Member 5 antibody
Anti-Multi-Specific Organic Anion Transporter C antibody
Anti-Moat-C antibody
Anti-Multidrug Resistance-Associated Protein 5 antibody
Anti-Smrp antibody
Anti-Pabc11 antibody
Anti-ABCC5 antibody
Anti-MRP5 antibody

Information sourced from

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