Anti-ABCA3 antibody (450-530) (STJ190577)


Current Stock:
Host: Rabbit
Applications: WB, ELISA
Reactivity: Human, Mouse
Short Description: Rabbit polyclonal antibody anti-Phospholipid-Transporting Atpase Abca3 (450-530) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS, 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit anti-serum by affinity-chromatography.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ABCA3
Gene ID: 21
Immunogen Region: 450-530
Specificity: ABCA3 polyclonal antibody (Phospholipid-Transporting Atpase Abca3) binds to endogenous Phospholipid-Transporting Atpase Abca3 at the amino acid region 450-530.
Immunogen: Synthesized peptide derived from human protein at aa range 450-530
Post Translational Modifications N-glycosylated. Localization at intracellular vesicles is accompanied by processing of oligosaccharide from high mannose type to complex type. N-linked glycosylation at Asn-124 and Asn-140 is required for stability and efficient anterograde trafficking and prevents from proteasomal degradation. Proteolytically cleaved by CTSL and to a lower extent by CTSB within multivesicular bodies (MVB) and lamellar bodies (LB) leading to a mature form of 150 kDa.
Function Catalyzes the ATP-dependent transport of phospholipids such as phosphatidylcholine and phosphoglycerol from the cytoplasm into the lumen side of lamellar bodies, in turn participates in the lamellar bodies biogenesis and homeostasis of pulmonary surfactant. Transports preferentially phosphatidylcholine containing short acyl chains. In addition plays a role as an efflux transporter of miltefosine across macrophage membranes and free cholesterol (FC) through intralumenal vesicles by removing FC from the cell as a component of surfactant and protects cells from free cholesterol toxicity.
Protein Name Phospholipid-Transporting Atpase Abca3
Abc-C Transporter
Atp-Binding Cassette Sub-Family A Member 3
Atp-Binding Cassette Transporter 3
Atp-Binding Cassette 3
Xenobiotic-Transporting Atpase Abca3 Cleaved Into - 150 Kda Mature Form
Database Links Reactome: R-HSA-1369062
Reactome: R-HSA-5683678
Reactome: R-HSA-5683826
Reactome: R-HSA-5688399
Cellular Localisation Endosome
Multivesicular Body Membrane
Multi-Pass Membrane Protein
Cytoplasmic Vesicle Membrane
Late Endosome Membrane
Lysosome Membrane
Localized In The Limiting Membrane Of Lamellar Bodies In Lung Alveolar Type Ii Cells
Trafficks Via The Golgi
Sorting Vesicles (Svs) And Late Endosome/Multivesicular Body Network Directly To The Outer Membrane Of Lamellar Bodies In At2 Lung Epithelial Cells Or To Lysosomes And Lysosomal-Related Organelles (Lros) In Other Cells Where Undergoes Proteolytic Cleveage And Oligosaccharide Processing From High Mannose Type To Complex Type
Oligomers Formation Takes Place In A Post-Endoplasmic Reticulum Compartment
Alternative Antibody Names Anti-Phospholipid-Transporting Atpase Abca3 antibody
Anti-Abc-C Transporter antibody
Anti-Atp-Binding Cassette Sub-Family A Member 3 antibody
Anti-Atp-Binding Cassette Transporter 3 antibody
Anti-Atp-Binding Cassette 3 antibody
Anti-Xenobiotic-Transporting Atpase Abca3 Cleaved Into - 150 Kda Mature Form antibody
Anti-ABCA3 antibody
Anti-ABC3 antibody

Information sourced from

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