| Tissue Specificity | Most abundant in heart, spleen and lung. |
| Post Translational Modifications | Phosphorylated by PRKCD. |
| Function | Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors (Probable). Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13. Also, during inflammation, mediates zymosan-induced increase intracellular cAMP, leading to protein kinase A pathway activation in order to modulate innate immune responses through heterotrimeric G proteins G(12/13). Functions in signaling cascades activated namely by dopamine and C5 alpha chain and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G protein with G beta:gamma complex. Functions, through cAMP response regulation, to keep inflammation under control during bacterial infection by sensing the presence of serum factors, such as the bioactive lysophospholipid (LPA) that regulate LPS-induced TNF-alpha production. However, it is also required for the optimal functions of B and T cells during adaptive immune responses by regulating cAMP synthesis in both B and T cells. |
| Peptide Name | Adenylate Cyclase Type 7Atp Pyrophosphate-Lyase 7Adenylate Cyclase Type ViiAdenylyl Cyclase 7 |
| Database Links | Reactome: R-MMU-163615Reactome: -MMU-170660Reactome: -MMU-170670Reactome: -MMU-418597Reactome: -MMU-5610787 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Peptide Names | Adenylate Cyclase Type 7 proteinAtp Pyrophosphate-Lyase 7 proteinAdenylate Cyclase Type Vii proteinAdenylyl Cyclase 7 proteinAdcy7 protein |
Information sourced from Uniprot.org
