| Tissue Specificity | In testis, expressed in Sertoli cells, peritubular myoid cells and in germinal cells. Highest levels in Sertoli cells. |
| Post Translational Modifications | Stearoylated by ZDHHC6 which inhibits TFRC-mediated activation of the JNK pathway and promotes mitochondrial fragmentation. Stearoylation does not affect iron uptake. N- and O-glycosylated, phosphorylated and palmitoylated. |
| Function | Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Positively regulates T and B cell proliferation through iron uptake. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway. When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion. When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2. Mediates uptake of NICOL1 into fibroblasts where it may regulate extracellular matrix production. |
| Protein Name | Transferrin Receptor Protein 1TrTfrTfr1TrfrCd Antigen Cd71 |
| Database Links | Reactome: R-RNO-432722Reactome: -RNO-8856825Reactome: -RNO-8856828Reactome: -RNO-8980692Reactome: -RNO-9013026Reactome: -RNO-9013149Reactome: -RNO-9013404Reactome: -RNO-9013406Reactome: -RNO-9013407Reactome: -RNO-9013408Reactome: -RNO-917977Reactome: -RNO-9696270Reactome: -RNO-9696273 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinMelanosome |
| Alternative ELISA Names | Transferrin Receptor Protein 1 ELISA kitTr ELISA kitTfr ELISA kitTfr1 ELISA kitTrfr ELISA kitCd Antigen Cd71 ELISA kitTfrc ELISA kitTrfr ELISA kit |
| output | |
Information sourced from Uniprot.org
