| Tissue Specificity | Highly expressed in kidney, heart, white adipose tissue, lung and spleen. |
| Post Translational Modifications | Phosphorylated when associated with the catalytic subunit (PRKAA1 or PRKAA2). Phosphorylated by ULK1.leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and AMPK. |
| Function | Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton.probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). |
| Protein Name | 5'-Amp-Activated Protein Kinase Subunit Beta-1Ampk Subunit Beta-1Ampkb5'-Amp-Activated Protein Kinase 40 Kda Subunit |
| Database Links | Reactome: R-RNO-1632852Reactome: -RNO-380972Reactome: -RNO-5628897Reactome: -RNO-6804756 |
| Cellular Localisation | |
| Alternative ELISA Names | 5'-Amp-Activated Protein Kinase Subunit Beta-1 ELISA kitAmpk Subunit Beta-1 ELISA kitAmpkb ELISA kit5'-Amp-Activated Protein Kinase 40 Kda Subunit ELISA kitPrkab1 ELISA kit |
| output | |
Information sourced from Uniprot.org
