| Applications: | ELISA |
| Reactivity: | Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.61ng/mL |
| Detection Limit: | 1.56-100ng/mL |
| Short Description : | This ANGPTL4 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat serum, plasma, tissue homogenates, cell lysates or other biological fluids.. |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
| Gene Symbol: | Angptl4 |
| Gene ID: | 362850 |
| Uniprot ID: | ANGL4_RAT |
| Sample Type: | serum, plasma, tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | N-glycosylated. ANGPTL4 N-terminal chain: Forms disulfide-linked dimers and tetramers. Cleaved into a smaller N-terminal chain and a larger chain that contains the fibrinogen C-terminal domain.both cleaved and uncleaved forms are detected in the extracellular space. The cleaved form is not present within the cell. |
| Function | Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro). Depending on context, may modulate tumor-related angiogenesis. ANGPTL4 N-terminal chain: Mediates inactivation of the lipoprotein lipase LPL, and thereby plays an important role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. Has higher activity in LPL inactivation than the uncleaved protein. |
| Protein Name | Angiopoietin-Related Protein 4 Angiopoietin-Like Protein 4 Hepatic Fibrinogen/Angiopoietin-Related Protein Hfarp Cleaved Into - Angptl4 N-Terminal Chain - Angptl4 C-Terminal Chain |
| Database Links | Reactome: R-RNO-8963889 Reactome: -RNO-9762292 |
| Cellular Localisation | Secreted Extracellular Space Extracellular Matrix The Unprocessed Form Interacts With The Extracellular Matrix This May Constitute A Dynamic Reservoir A Regulatory Mechanism Of The Bioavailability Of Angptl4 |
| Alternative ELISA Names | Angiopoietin-Related Protein 4 ELISA kit Angiopoietin-Like Protein 4 ELISA kit Hepatic Fibrinogen/Angiopoietin-Related Protein ELISA kit Hfarp Cleaved Into - Angptl4 N-Terminal Chain - Angptl4 C-Terminal Chain ELISA kit Angptl4 ELISA kit |
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Information sourced from Uniprot.org