Mouse SOCS2 (Suppressors Of Cytokine Signaling 2) Sandwich ELISA Kit Kit (STJE0012260)

Mouse SOCS2 (Suppressors Of Cytokine Signaling 2) Sandwich ELISA Kit Kit (STJE0012260)

SKU:
STJE0012260
£476.50 - £651.50
Free Shipping
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.066ng/mL
Detection Limit: 0.156-10ng/mL
Short Description : This SOCS2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse tissue homogenates or other biological fluids..
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: Socs2
Gene ID: 216233
Uniprot ID: SOCS2_MOUSE
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Expressed primarily in the testis, some expression in liver and lung.
Post Translational Modifications Ubiquitinated.mediated by AREL1 and leading to its subsequent proteasomal degradation. Ubiquitination is dependent on phosphorylation at Ser-52, by PKC and is stimulated by LPS. Phosphorylation at Ser-52 by PKC facilitates its ubiquitination and proteasomal degradation.
Function Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as EPOR and GHR. Specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination. The ECS(SOCS2) complex acts as a key regulator of growth hormone receptor (GHR) levels by mediating ubiquitination and degradation of GHR, following GHR phosphorylation by JAK2. The ECS(SOCS2) also catalyzes ubiquitination and degradation of JAK2-phosphorylated EPOR.
Protein Name Suppressor Of Cytokine Signaling 2
Socs-2
Database Links Reactome: R-MMU-8951664
Reactome: -MMU-9706369
Cellular Localisation Cytoplasm
Alternative ELISA Names Suppressor Of Cytokine Signaling 2 ELISA kit
Socs-2 ELISA kit
Socs2 ELISA kit
output

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJE0012259 Human SOCS2 (Suppressors Of Cytokine Signaling 2) Sandwich ELISA Kit Kit (STJE0012259) Human ELISA
STJE0018647 Mouse SOCS2 (Suppressors Of Cytokine Signaling 2) Sandwich ELISA Kit Ready-To-Use Kit (STJE0018647) Mouse ELISA
STJE0012261 Rat SOCS2 (Suppressors Of Cytokine Signaling 2) Sandwich ELISA Kit Kit (STJE0012261) Rat ELISA
STJE0018648 Rat SOCS2 (Suppressors Of Cytokine Signaling 2) Sandwich ELISA Kit Ready-To-Use Kit (STJE0018648) Rat ELISA
STJE0018646 Human SOCS2 (Suppressors Of Cytokine Signaling 2) Sandwich ELISA Kit Ready-To-Use Kit (STJE0018646) Human ELISA
!