Mouse SGPL1 (Sphingosine 1 Phosphate Lyase 1) Sandwich ELISA Kit Kit (STJE0012140)

Mouse SGPL1 (Sphingosine 1 Phosphate Lyase 1) Sandwich ELISA Kit Kit (STJE0012140)

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STJE0012140
£476.50 - £651.50
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Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.055ng/mL
Detection Limit: 0.156-10ng/mL
Short Description : This SGPL1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse tissue homogenates or other biological fluids..
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: Sgpl1
Gene ID: 20397
Uniprot ID: SGPL1_MOUSE
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Highest levels are found in liver, small intestine and thymus, followed by kidney, lung, heart, spleen and brain (at protein level). Also detected in stomach, testis and skeletal muscle (at protein level).
Post Translational Modifications
Function Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP. Seems to play a role in establishing neuronal contact sites and axonal maintenance.
Protein Name Sphingosine-1-Phosphate Lyase 1
S1pl
Sp-Lyase 1
Spl 1
Mspl
Sphingosine-1-Phosphate Aldolase
Database Links Reactome: R-MMU-9845614
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Type Iii Membrane Protein
Cytoplasmic Side
Alternative ELISA Names Sphingosine-1-Phosphate Lyase 1 ELISA kit
S1pl ELISA kit
Sp-Lyase 1 ELISA kit
Spl 1 ELISA kit
Mspl ELISA kit
Sphingosine-1-Phosphate Aldolase ELISA kit
Sgpl1 ELISA kit
Spl ELISA kit
output

Information sourced from Uniprot.org

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