| Function | Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages. |
| Protein Name | Interferon Regulatory Factor 3Irf-3 |
| Database Links | Reactome: R-MMU-1169408Reactome: -MMU-1606341Reactome: -MMU-168928Reactome: -MMU-3134973Reactome: -MMU-3134975Reactome: -MMU-3270619Reactome: -MMU-9013973Reactome: -MMU-918233Reactome: -MMU-933541Reactome: -MMU-936440Reactome: -MMU-936964 |
| Cellular Localisation | CytoplasmNucleusMitochondrionShuttles Between Cytoplasmic And Nuclear CompartmentsWith Export Being The Prevailing EffectWhen ActivatedIrf3 Interaction With Crebbp Prevents Its Export To The CytoplasmRecruited To Mitochondria Via Tomm70:Hsp90aa1 Upon Sendai Virus Infection |
| Alternative Protein Names | Interferon Regulatory Factor 3 proteinIrf-3 proteinIrf3 protein |
Information sourced from Uniprot.org
