• Mouse IL-36Ra/IL-1F5 protein (Recombinant) (No-Tag) (STJP001975)

Mouse IL-36Ra/IL-1F5 protein (Recombinant) (No-Tag) (STJP001975)

SKU:
STJP001975

£97.50 - £291.50
Current Stock:
Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: ＜1 EU/Mu g
Gene Symbol: IL36RN
Gene ID: 54450
Uniprot ID: I36RA_MOUSE
Immunogen Region: Val3-Asp156
Immunogen: Recombinant Mouse IL-36Ra/IL-1F5 Protein is produced by expression system. The target protein is expressed with sequence (Val3-Asp156) of mouse IL-36Ra/IL-1F5 (Accession #NP_062324.2) fused with no additional amino acid.
Immunogen Sequence: VLSGALCFRMKDSALKVLYL HNNQLLAGGLHAEKVIKGEE ISVVPNRALDASLSPVILGV QGGSQCLSCGTEKGPILKLE PVNIMELYLGAKESKSFTFY RRDMGLTSSFESAAYPGWFL CTSPEADQPVRLTQIPEDPA WDAPITDFYFQQCD
Post Translational Modifications Removal of N-terminal methionine is necessary for full antagonistic activity.
Function Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2/IL-36R and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response.similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR.
Protein Name Interleukin-36 Receptor Antagonist Protein
Il-36ra
Interleukin-1 Hy1
Il-1hy1
Interleukin-1 Delta
Il-1 Delta
Interleukin-1 Family Member 5
Il-1f5
Interleukin-1 Homolog 3
Il-1h3
Interleukin-1-Like Protein 1
Il-1l1
Database Links Reactome: R-MMU-9014826
Cellular Localisation Cytoplasm
Secreted
The Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10
It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion
Alternative Protein Names Interleukin-36 Receptor Antagonist Protein protein
Il-36ra protein
Interleukin-1 Hy1 protein
Il-1hy1 protein
Interleukin-1 Delta protein
Il-1 Delta protein
Interleukin-1 Family Member 5 protein
Il-1f5 protein
Interleukin-1 Homolog 3 protein
Il-1h3 protein
Interleukin-1-Like Protein 1 protein
Il-1l1 protein
IL36RN protein
Fil1d protein
Il1f5 protein
Il1h3 protein
Il1hy1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance