| Post Translational Modifications | Phosphorylation at Ser-298 of the linker region decreases the binding to H3K9me3. Phosphorylation at Ser-639 by CDK1 during M phase impairs interaction with USP7, preventing deubiquitination and leading to degradation by the proteasome. Ubiquitinated.which leads to proteasomal degradation. Autoubiquitinated.interaction with USP7 leads to deubiquitination and prevents degradation. Ubiquitination and degradation takes place during M phase, when phosphorylation at Ser-639 prevents interaction with USP7 and subsequent deubiquitination. Polyubiquitination may be stimulated by DNA damage. |
| Function | Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. Plays a role in DNA repair by cooperating with UHRF2 to ensure recruitment of FANCD2 to interstrand cross-links (ICLs) leading to FANCD2 activation. Acts as a critical player of proper spindle architecture by catalyzing the 'Lys-63'-linked ubiquitination of KIF11, thereby controlling KIF11 localization on the spindle. |
| Protein Name | E3 Ubiquitin-Protein Ligase Uhrf1Inverted Ccaat Box-Binding Protein Of 90 KdaNuclear Protein 95Nuclear Zinc Finger Protein Np95Hunp95Hnp95Ring Finger Protein 106Ring-Type E3 Ubiquitin Transferase Uhrf1Transcription Factor Icbp90Ubiquitin-Like Phd And Ring Finger Domain-Containing Protein 1Huhrf1Ubiquitin-Like-Containing Phd And Ring Finger Domains Protein 1 |
| Database Links | Reactome: R-HSA-5334118Reactome: R-HSA-9821002 |
| Cellular Localisation | NucleusAssociatedThrough The Ydg Domain (Also Called Sra Domain)With Replicating Dna From Early To Late S PhaseIncluding At Replicating Pericentric HeterochromatinAlso Localizes To Euchromatic RegionsIn Non-S-Phase CellsHomogenously Distributed Through The Nucleus |
| Alternative Protein Names | E3 Ubiquitin-Protein Ligase Uhrf1 proteinInverted Ccaat Box-Binding Protein Of 90 Kda proteinNuclear Protein 95 proteinNuclear Zinc Finger Protein Np95 proteinHunp95 proteinHnp95 proteinRing Finger Protein 106 proteinRing-Type E3 Ubiquitin Transferase Uhrf1 proteinTranscription Factor Icbp90 proteinUbiquitin-Like Phd And Ring Finger Domain-Containing Protein 1 proteinHuhrf1 proteinUbiquitin-Like-Containing Phd And Ring Finger Domains Protein 1 proteinUHRF1 proteinICBP90 proteinNP95 proteinRNF106 protein |
Information sourced from Uniprot.org
