Human SVIL protein (Recombinant) (N-His) (STJP003428)

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STJP003428
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SVIL-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: SVIL
Gene ID: 6840
Uniprot ID: SVIL_HUMAN
Immunogen Region: Val1385-Thr1525
Immunogen: Homo sapiens (Human)
Function Isoform 1: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation. Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function. Isoform 2: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction.
Protein Name Supervillin
Archvillin
P205/P250
Cellular Localisation Cell Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Cytoplasm
Cytoskeleton
Cell Projection
Invadopodium
Podosome
Midbody
Cleavage Furrow
Tightly Associated With Both Actin Filaments And Plasma Membranes
Alternative Protein Names Supervillin protein
Archvillin protein
P205/P250 protein
SVIL protein

Information sourced from Uniprot.org

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