| Function | Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63. |
| Protein Name | Fact Complex Subunit Ssrp1Chromatin-Specific Transcription Elongation Factor 80 Kda SubunitFacilitates Chromatin Transcription Complex 80 Kda SubunitFact 80 Kda SubunitFactp80Facilitates Chromatin Transcription Complex Subunit Ssrp1Recombination Signal Sequence Recognition Protein 1Structure-Specific Recognition Protein 1Hssrp1T160 |
| Database Links | Reactome: R-HSA-112382Reactome: R-HSA-167152Reactome: R-HSA-167200Reactome: R-HSA-167238Reactome: R-HSA-167243Reactome: R-HSA-167246Reactome: R-HSA-167287Reactome: R-HSA-167290Reactome: R-HSA-674695Reactome: R-HSA-6796648Reactome: R-HSA-6804756Reactome: R-HSA-75955 |
| Cellular Localisation | NucleusNucleolusChromosomeColocalizes With Rna Polymerase Ii On ChromatinRecruited To Actively Transcribed Loci |
| Alternative Protein Names | Fact Complex Subunit Ssrp1 proteinChromatin-Specific Transcription Elongation Factor 80 Kda Subunit proteinFacilitates Chromatin Transcription Complex 80 Kda Subunit proteinFact 80 Kda Subunit proteinFactp80 proteinFacilitates Chromatin Transcription Complex Subunit Ssrp1 proteinRecombination Signal Sequence Recognition Protein 1 proteinStructure-Specific Recognition Protein 1 proteinHssrp1 proteinT160 proteinSSRP1 proteinFACT80 protein |
Information sourced from Uniprot.org
