| Function | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in pre-mRNA splicing as component of the spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly. The protein undergoes a conformational change upon RNA-binding. |
| Protein Name | Nhp2-Like Protein 1High Mobility Group-Like Nuclear Protein 2 Homolog 1Otk27Snu13 HomologHsnu13U4/U6.U5 Small Nuclear Ribonucleoprotein Snu13U4/U6.U5 Tri-Snrnp 15.5 Kda Protein Cleaved Into - Nhp2-Like Protein 1 - N-Terminally Processed |
| Database Links | Reactome: R-HSA-6790901Reactome: R-HSA-6791226Reactome: R-HSA-72163 |
| Cellular Localisation | NucleusNucleolusConcentrated In The Dense Fibrillar Component Of The Nucleolus |
| Alternative Protein Names | Nhp2-Like Protein 1 proteinHigh Mobility Group-Like Nuclear Protein 2 Homolog 1 proteinOtk27 proteinSnu13 Homolog proteinHsnu13 proteinU4/U6.U5 Small Nuclear Ribonucleoprotein Snu13 proteinU4/U6.U5 Tri-Snrnp 15.5 Kda Protein Cleaved Into - Nhp2-Like Protein 1 - N-Terminally Processed proteinSNU13 proteinNHP2L1 protein |
Information sourced from Uniprot.org
