| Post Translational Modifications | Phosphorylated by PIM1 in vitro. |
| Function | Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition. Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Functions as a transcriptional coactivator for STAT5. (Microbial infection) Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2). (Microbial infection) Promotes SARS-CoV-2 RNA synthesis by binding to negative-sense RNA and the viral protein nsp9. |
| Protein Name | Staphylococcal Nuclease Domain-Containing Protein 1100 Kda CoactivatorEbna2 Coactivator P100Tudor Domain-Containing Protein 11P100 Co-Activator |
| Database Links | Reactome: R-HSA-6802952 |
| Cellular Localisation | CytoplasmNucleusMelanosomeIn Il-4 Stimulated Cells Colocalizes With Stat6 In The NucleusIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv |
| Alternative Protein Names | Staphylococcal Nuclease Domain-Containing Protein 1 protein100 Kda Coactivator proteinEbna2 Coactivator P100 proteinTudor Domain-Containing Protein 11 proteinP100 Co-Activator proteinSND1 proteinTDRD11 protein |
Information sourced from Uniprot.org
