Human SIGLEC8/SAF-2 protein (Recombinant) (C-Fc) (STJP006926)

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STJP006926
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SIGLEC8/SAF-2-C-Fc protein was developed from mammalian cells and has a target region of C-Fc. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: SIGLEC8
Gene ID: 27181
Uniprot ID: SIGL8_HUMAN
Immunogen Region: Met1-Ala363
Immunogen: Homo sapiens (Human)
Function Putative adhesion molecule that mediates sialic-acid dependent binding to blood cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. Recognizes simultaneously epitopes having a terminal N-acetylneuraminic acid (sialic acid) and an underlying 6-O-sulfated galactose. Preferentially binds to Gal-6-sulfated sialyl-Lewis X glycan epitopes.
Protein Name Sialic Acid-Binding Ig-Like Lectin 8
Siglec-8
Sialoadhesin Family Member 2
Saf-2
Database Links Reactome: R-HSA-198933
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Sialic Acid-Binding Ig-Like Lectin 8 protein
Siglec-8 protein
Sialoadhesin Family Member 2 protein
Saf-2 protein
SIGLEC8 protein
SAF2 protein

Information sourced from Uniprot.org

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