| Function | E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria. LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin. The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation. Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types. |
| Protein Name | Ranbp-Type And C3hc4-Type Zinc Finger-Containing Protein 1Hbv-Associated Factor 4Heme-Oxidized Irp2 Ubiquitin Ligase 1Hoil-1Hepatitis B Virus X-Associated Protein 4Ring Finger Protein 54Ring-Type E3 Ubiquitin Transferase Hoil-1Ubiquitin-Conjugating Enzyme 7-Interacting Protein 3 |
| Database Links | Reactome: R-HSA-5357786Reactome: R-HSA-5357905Reactome: R-HSA-5357956Reactome: R-HSA-983168 |
| Alternative Protein Names | Ranbp-Type And C3hc4-Type Zinc Finger-Containing Protein 1 proteinHbv-Associated Factor 4 proteinHeme-Oxidized Irp2 Ubiquitin Ligase 1 proteinHoil-1 proteinHepatitis B Virus X-Associated Protein 4 proteinRing Finger Protein 54 proteinRing-Type E3 Ubiquitin Transferase Hoil-1 proteinUbiquitin-Conjugating Enzyme 7-Interacting Protein 3 proteinRBCK1 proteinC20orf18 proteinRNF54 proteinUBCE7IP3 proteinXAP3 proteinXAP4 protein |
Information sourced from Uniprot.org
