| Tissue Specificity | Expressed specifically in testis and sperm. Weakly expressed in pancreatic-duct cells. Up-regulated in pancreatic-duct cells from patients with cystic fibrosis. |
| Post Translational Modifications | |
| Function | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. |
| Protein Name | 1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Zeta-1Phosphoinositide Phospholipase C-Zeta-1Phospholipase C-Zeta-1Plc-Zeta-1Testis-Development Protein Nyd-Sp27 |
| Database Links | Reactome: R-HSA-1855204 |
| Cellular Localisation | NucleusCytoplasmPerinuclear RegionExhibits Alternative Cytoplasmic/Nuclear Localization During DevelopmentTranslocates From The Pronucleus Into Cytoplasm Upon Nuclear Envelope Breakdown For Mitosis And Localizes Again To The Pronucleus At Interphase Following Meiosis And Mitosis |
| Alternative ELISA Names | 1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Zeta-1 ELISA kitPhosphoinositide Phospholipase C-Zeta-1 ELISA kitPhospholipase C-Zeta-1 ELISA kitPlc-Zeta-1 ELISA kitTestis-Development Protein Nyd-Sp27 ELISA kitPLCZ1 ELISA kit |
| output | |
Information sourced from Uniprot.org
