| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of 20mM Tris, 150mM NaCl, 5% Glycerol, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.01 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: | Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is typically 0.8-3.2 ng/mL, corresponding to a specific activity of 3.12×105-1.25×106units/mg. |
| Gene Symbol: | OSM |
| Gene ID: | 5008 |
| Uniprot ID: | ONCM_HUMAN |
| Immunogen Region: | Ala26-Arg221 |
| Immunogen: | Recombinant Human Oncostatin-M/OSM Protein is produced by E. coli expression system. The target protein is expressed with sequence (Ala26-Arg221) of human Oncostatin-M/OSM (Accession #NP_065391.1). |
| Immunogen Sequence: | AGPAAAVLRELRCVCLQTTQ GVHPKMISNLQVFAIGPQCS KVEVVASLKNGKEICLDPEA PFLKKVIQKILDGGNKEN |
| Post Translational Modifications | Propeptide processing is not important for receptor binding activity but may be important growth-inhibitory activity. |
| Function | Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration. |
| Protein Name | Oncostatin-MOsm |
| Database Links | Reactome: R-HSA-6785807Reactome: R-HSA-6788467 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Oncostatin-M proteinOsm proteinOSM protein |
Information sourced from Uniprot.org
