| Function | Functions to regulate alternative splicing in neurons by binding pre-mRNA in a sequence-specific manner to activate exon inclusion or exclusion. It binds specifically to the sequences 5'-YCAY-3' and regulates splicing in only a subset of regulated exons. Binding to an exonic 5'-YCAY-3' cluster changes the protein complexes assembled on pre-mRNA, blocking U1 snRNP binding and exon inclusion, whereas binding to an intronic 5'-YCAY-3' cluster enhances spliceosome assembly and exon inclusion. Binding to 5'-YCAY-3' clusters results in a local and asymmetric action to regulate spliceosome assembly and alternative splicing in neurons. Binding to an exonic 5'-YCAY-3' cluster changed the protein complexes assembled on pre-mRNA, blocking U1 snRNP (small nuclear ribonucleoprotein) binding and exon inclusion, whereas binding to an intronic 5'-YCAY-3' cluster enhanced spliceosome assembly and exon inclusion. With NOVA1, they perform unique biological functions in different brain areas and cell types. Autoregulates its own expression by acting as a splicing repressor. Acts to activate the inclusion of exon E3A in the glycine receptor alpha-2 chain and of exon E9 in gamma-aminobutyric-acid receptor gamma-2 subunit via a distal downstream UCAU-rich intronic splicing enhancer. Acts to regulate a novel glycine receptor alpha-2 chain splice variant (alpha-2N) in developing spinal cord. |
| Protein Name | Rna-Binding Protein Nova-1Neuro-Oncological Ventral Antigen 1Onconeural Ventral Antigen 1Paraneoplastic Ri AntigenVentral Neuron-Specific Protein 1 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Rna-Binding Protein Nova-1 proteinNeuro-Oncological Ventral Antigen 1 proteinOnconeural Ventral Antigen 1 proteinParaneoplastic Ri Antigen proteinVentral Neuron-Specific Protein 1 proteinNOVA1 protein |
Information sourced from Uniprot.org
