| Post Translational Modifications | Proteolytically cleaved by CASP8 downstream of TLR3 or TLR4, leading to its inactivation. Mainly cleaved at Asp-490 by CASP8. Cleaved by caspase-like protein MALT1 in T-cells following TCR-mediated activation, leading to its inactivation and subsequent viral reactivation during HIV-1 infection. Mono- and polyubiquitinated on the CoCUN region. Monoubiquitinated by NEDD4. Polyubiquitinated, leading to its degradation by the proteasome. Sumoylated with SUMO1, abrogating polyubiquitination and subsequent degradation. Desumoylated by SENP1, leading to accumulation in PML nuclear bodies. |
| Function | Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation. Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults. In response to more threatening pathogens, cleaved by CASP8 downstream of TLR3 or TLR4, leading to its inactivation, thereby allowing production of inflammatory cytokines. Acts as a restriction factor against some viruses, such as HIV-1: restricts HIV-1 replication by binding to HIV-1 mRNAs and mediating their degradation via its ribonuclease activity. Also acts as an inhibitor of the E3 ubiquitin-protein ligase ITCH: acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates. |
| Protein Name | Nedd4-Binding Protein 1N4bp1 |
| Database Links | Reactome: R-HSA-9758274 |
| Cellular Localisation | CytoplasmCytosolNucleusNucleolusPml BodyPrimarily Localizes To The NucleolusAlso Localizes To The Pml Nuclear BodiesWhen Desumoylated |
| Alternative Protein Names | Nedd4-Binding Protein 1 proteinN4bp1 proteinN4BP1 proteinKIAA0615 protein |
Information sourced from Uniprot.org
