Human LpPLA2/PLA2G7/PAF-AH protein (Recombinant) (C-His) (STJP009406)

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STJP009406
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human LpPLA2/PLA2G7/PAF-AH-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PLA2G7
Gene ID: 7941
Uniprot ID: PAFA_HUMAN
Immunogen Region: Met1-Asn441 (Val379Ala)
Immunogen: Homo sapiens (Human)
Post Translational Modifications N-glycosylated. Macrophage-derived PLA2G7 carries sialylated complex-type N-glycans that hinder its binding to HDL particles.
Function Lipoprotein-associated calcium-independent phospholipase A2 involved in phospholipid catabolism during inflammatory and oxidative stress response. At the lipid-aqueous interface, hydrolyzes the ester bond of fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity). Specifically targets phospholipids with a short-chain fatty acyl group at sn-2 position. Can hydrolyze phospholipids with long fatty acyl chains, only if they carry oxidized functional groups. Hydrolyzes and inactivates platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), a potent pro-inflammatory signaling lipid that acts through PTAFR on various innate immune cells. Hydrolyzes oxidatively truncated phospholipids carrying an aldehyde group at omega position, preventing their accumulation in low-density lipoprotein (LDL) particles and uncontrolled pro-inflammatory effects. As part of high-density lipoprotein (HDL) particles, can hydrolyze phospholipids having long-chain fatty acyl hydroperoxides at sn-2 position and protect against potential accumulation of these oxylipins in the vascular wall. Catalyzes the release from membrane phospholipids of F2-isoprostanes, lipid biomarkers of cellular oxidative damage.
Protein Name Platelet-Activating Factor Acetylhydrolase
Paf Acetylhydrolase
1-Alkyl-2-Acetylglycerophosphocholine Esterase
2-Acetyl-1-Alkylglycerophosphocholine Esterase
Group-Viia Phospholipase A2
Gviia-Pla2
Ldl-Associated Phospholipase A2
Ldl-Pla(2
Paf 2-Acylhydrolase
Database Links Reactome: R-HSA-422085
Cellular Localisation Secreted
Extracellular Space
Associates With Both Ldl And Hdl Particles In Plasma
Mainly Associates With Pro-Inflammatory Electronegative Ldl Particles
Alternative Protein Names Platelet-Activating Factor Acetylhydrolase protein
Paf Acetylhydrolase protein
1-Alkyl-2-Acetylglycerophosphocholine Esterase protein
2-Acetyl-1-Alkylglycerophosphocholine Esterase protein
Group-Viia Phospholipase A2 protein
Gviia-Pla2 protein
Ldl-Associated Phospholipase A2 protein
Ldl-Pla(2 protein
Paf 2-Acylhydrolase protein
PLA2G7 protein
PAFAH protein

Information sourced from Uniprot.org

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