| Post Translational Modifications | Phosphorylated on tyrosine by kinases of the SRC family such as SRC and YES as well as by the protein kinase C gamma/PRKCG. Dephosphorylated by phosphotyrosine phosphatases. Also phosphorylated by suramin, a heparin analog. Tyrosine phosphorylated in response to dissociation of integrin alpha-6 beta-4 from laminin-5. N-glycosylated. A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding). Another peptide of 80 kDa (p80) is present in cultured keratinocytes probably due to tryptic cleavage at an unidentified site on its N-terminal side. Converted to p80 by plasmin, a trypsin-like protease. |
| Function | May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis. |
| Protein Name | Cub Domain-Containing Protein 1Membrane Glycoprotein Gp140Subtractive Immunization M Plus Hep3-Associated 135 Kda ProteinSima135Transmembrane And Associated With Src KinasesCd Antigen Cd318 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Membrane ProteinShedding May Also Lead To A Soluble PeptideIsoform 3: Secreted |
| Alternative Protein Names | Cub Domain-Containing Protein 1 proteinMembrane Glycoprotein Gp140 proteinSubtractive Immunization M Plus Hep3-Associated 135 Kda Protein proteinSima135 proteinTransmembrane And Associated With Src Kinases proteinCd Antigen Cd318 proteinCDCP1 proteinTRASK proteinUNQ2486 proteinPRO5773 protein |
Information sourced from Uniprot.org
