| Post Translational Modifications | Phosphorylation at Ser-174 and Ser-175 by CSNK1D/CK1 promotes nuclear export. Ufmylated by UFL1. |
| Function | Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth. |
| Protein Name | Eukaryotic Translation Initiation Factor 6Eif-6B(2gcn HomologB4 Integrin InteractorCabP27(Bbp |
| Cellular Localisation | CytoplasmNucleusNucleolusShuttles Between Cytoplasm And Nucleus/Nucleolus |
| Alternative Protein Names | Eukaryotic Translation Initiation Factor 6 proteinEif-6 proteinB(2gcn Homolog proteinB4 Integrin Interactor proteinCab proteinP27(Bbp proteinEIF6 proteinEIF3A proteinITGB4BP proteinOK proteinSW-cl.27 protein |
Information sourced from Uniprot.org
