| Post Translational Modifications | Phosphorylated by ATM kinase.phosphorylation is increased in response to ionizing radiation (IR). |
| Function | Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1. Specifically binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA. (Microbial infection) Required for HIV-1 Rev function as well as for HIV-1 and coronavirus IBV replication. Binds to the RRE sequence of HIV-1 mRNAs. (Microbial infection) Required for Coronavirus IBV replication. |
| Protein Name | Atp-Dependent Rna Helicase Ddx1Dead Box Protein 1Dead Box Protein RetinoblastomaDbp-Rb |
| Database Links | Reactome: R-HSA-6784531 |
| Cellular Localisation | NucleusCytoplasmCytoplasmic GranuleCytosolMitochondrionLocalized With Mbnl1Tial1 And Ybx1 In Stress Granules Upon StressLocalized With Cstf2 In Cleavage BodiesForms Large Aggregates Called Ddx1 BodiesRelocalized Into Multiple Foci (Ir-Induced Foci Or Irif) After Ir TreatmentA Process That Depends On The Presence Of Chromosomal Dna And/Or Rna-Dna DuplexesRelocalized At Sites Of Dna Double-Strand Breaks (Dsbs) In An Atm-Dependent Manner After Ir TreatmentColocalized With Rela In The Nucleus Upon Tnf-Alpha InductionEnters Into The Nucleus In Case Of Active Transcription While It Accumulates In Cytosol When Transcription Level Is LowColocalizes In The Cytosol With Ddx21Dhx36 And Ticam1Colocalizes In The Mitochondria With Ticam1 And Poly(I:c) Rna LigandThe Multi-Helicase-Ticam1 Complex May Translocate To The Mitochondria Upon Poly(I:c) Stimulation(Microbial Infection) Relocalized To The Cytoplasm With A Perinuclear Staining Pattern In Avian Infectious Bronchitis Virus (Ibv)-Infected CellsRequired For Proper Localization Of Hiv-1 Rev |
| Alternative Protein Names | Atp-Dependent Rna Helicase Ddx1 proteinDead Box Protein 1 proteinDead Box Protein Retinoblastoma proteinDbp-Rb proteinDDX1 protein |
Information sourced from Uniprot.org
