Recombinant Human CXCL7/PPBP Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 10-15 kDa.

Human CXCL7/PPBP protein (Recombinant) (C-hFc&6*His) (STJP002976)

SKU:
STJP002976
£97.50 - £211.50
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Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: Please contact us for more information.
Gene Symbol: PPBP
Gene ID: 5473
Uniprot ID: CXCL7_HUMAN
Immunogen Region: Ala59-Asp128
Immunogen: Recombinant Human CXCL7/PPBP Protein is produced by E. coli expression system. The target protein is expressed with sequence (Ala59-Asp128) of human CXCL7/PPBP (Accession #NP_002695.1) fused with no additional amino acid.
Immunogen Sequence: MDMFPLTWVFLALYFSRHQV RGQPDPPCGGRLNSKDAGYI TSPGSPQDYPSHQNCEWIVY APEPNQKIVLNFNPHFEIEK HDCKYDFIEIRDGDSESADL LGKHCGNIAPPTIISSGSML YIKFTSDYARQGAGFSLRYE IFKTGSEDCSKNFTSPNGTI ESPGFPEKYPHNLDCTFTIL AKPKMEIILQFLIFDLEHDP LQVGEGDCKYDWLDIWDGIP HVGPLIGKYCGTKTPSELR
Post Translational Modifications Proteolytic removal of residues 1-9 produces the active peptide connective tissue-activating peptide III (CTAP-III) (low-affinity platelet factor IV (LA-PF4)). Proteolytic removal of residues 1-13 produces the active peptide beta-thromboglobulin, which is released from platelets along with platelet factor 4 and platelet-derived growth factor. NAP-2(1-66) is produced by proteolytical processing, probably after secretion by leukocytes other than neutrophils. NAP-2(73) and NAP-2(74) seem not be produced by proteolytical processing of secreted precursors but are released in an active form from platelets.
Function LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation.
Protein Name Platelet Basic Protein
Pbp
C-X-C Motif Chemokine 7
Leukocyte-Derived Growth Factor
Ldgf
Macrophage-Derived Growth Factor
Mdgf
Small-Inducible Cytokine B7 Cleaved Into - Connective Tissue-Activating Peptide Iii
Ctap-Iii
La-Pf4
Low-Affinity Platelet Factor Iv - Tc-2 - Connective Tissue-Activating Peptide Iii(1-81
Ctap-Iii(1-81 - Beta-Thromboglobulin
Beta-Tg - Neutrophil-Activating Peptide 2(74
Nap-2(74 - Neutrophil-Activating Peptide 2(73
Nap-2(73 - Neutrophil-Activating Peptide 2
Nap-2 - Tc-1 - Neutrophil-Activating Peptide 2(1-66
Nap-2(1-66 - Neutrophil-Activating Peptide 2(1-63
Nap-2(1-63
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-380108
Reactome: R-HSA-418594
Reactome: R-HSA-6798695
Cellular Localisation Secreted
Alternative Protein Names Platelet Basic Protein protein
Pbp protein
C-X-C Motif Chemokine 7 protein
Leukocyte-Derived Growth Factor protein
Ldgf protein
Macrophage-Derived Growth Factor protein
Mdgf protein
Small-Inducible Cytokine B7 Cleaved Into - Connective Tissue-Activating Peptide Iii protein
Ctap-Iii protein
La-Pf4 protein
Low-Affinity Platelet Factor Iv - Tc-2 - Connective Tissue-Activating Peptide Iii(1-81 protein
Ctap-Iii(1-81 - Beta-Thromboglobulin protein
Beta-Tg - Neutrophil-Activating Peptide 2(74 protein
Nap-2(74 - Neutrophil-Activating Peptide 2(73 protein
Nap-2(73 - Neutrophil-Activating Peptide 2 protein
Nap-2 - Tc-1 - Neutrophil-Activating Peptide 2(1-66 protein
Nap-2(1-66 - Neutrophil-Activating Peptide 2(1-63 protein
Nap-2(1-63 protein
PPBP protein
CTAP3 protein
CXCL7 protein
SCYB7 protein
TGB1 protein
THBGB1 protein

Information sourced from Uniprot.org

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