| Post Translational Modifications | Palmitoylated. Palmitoylation by ZDHHC2 regulates CD151 expression, association with other tetraspanin family proteins and function in cell adhesion. Ubiquitinated by RNF128 on lysine residues present in the tetraspanin amino terminus via 'Lys-48'-linked ubiquitin leading to proteasomal degradation. |
| Function | Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Plays a role in various cellular and molecular mechanism through its association with both integrin and non-integrin proteins. These interactions facilitate critical cellular functions, including cell-to-cell communication, wound healing, platelet aggregation, trafficking, cell motility, and angiogenesis. Via interaction with JAM-A/F11R and integrin ITGA3:ITGB1, promotes the recruitment of signaling molecules such as RAC1, CDC42 and RhoGTPases to facilitate the polarization of epithelial cells and the reorganization of the actin cytoskeleton, which are critical steps in cell migration process. Regulates the glycosylation pattern of ITGA3:ITGB1 thereby modulating its activity. Plays an essential role in the maintenance of central laminin-binding integrin ITGA6:ITGB4-containing adhesion complexes. Essential for the proper assembly of the glomerular and tubular basement membranes in kidney. Contributes to T-cell activation by modulating integrin signaling leading to activation of downstream targets PTK2 and MAPK1/MAPK3. (Microbial infection) Plays a role in human papillomavirus 16/HPV-16 endocytosis upon binding to cell surface receptor. (Microbial infection) Plays a role in human cytomegalovirus entry into host cell by contributing to entry receptor binding, membrane fusion, or release of the capsid. |
| Protein Name | Cd151 AntigenGp27Membrane Glycoprotein Sfa-1Platelet-Endothelial Tetraspan Antigen 3Peta-3Tetraspanin-24Tspan-24Cd Antigen Cd151 |
| Database Links | Reactome: R-HSA-2022090Reactome: R-HSA-446107 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinRelocalizes To The Immune Synapse In T-Cells Upon Activation |
| Alternative Protein Names | Cd151 Antigen proteinGp27 proteinMembrane Glycoprotein Sfa-1 proteinPlatelet-Endothelial Tetraspan Antigen 3 proteinPeta-3 proteinTetraspanin-24 proteinTspan-24 proteinCd Antigen Cd151 proteinCD151 proteinTSPAN24 protein |
Information sourced from Uniprot.org
