Human CD110/MPL protein (Recombinant) (N-His) (STJP004679)

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STJP004679
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CD110/MPL-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: MPL
Gene ID: 4352
Uniprot ID: TPOR_HUMAN
Immunogen Region: Ser311-Gln460
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated at Tyr-591 in response to THPO stimulation. Ubiquitination at Lys-553 and Lys-573 targets MPL for degradation by both the lysosomal and proteasomal pathways. The E3 ubiquitin-protein ligase CBL significantly contributes to this ubiquitination.
Function Receptor for thrombopoietin that regulates hematopoietic stem cell renewal, megakaryocyte differentiation, and platelet formation. Upon activation by THPO, induces rapid tyrosine phosphorylation and activation of JAK2, providing docking sites for many signaling proteins such as STAT5, SHIP/INPP5D, GRB2, SOS1 and PI3K. In turn, These signaling cascades lead to the proliferation, survival, and differentiation of megakaryocytes, ultimately leading to increased platelet production.
Protein Name Thrombopoietin Receptor
Tpo-R
Myeloproliferative Leukemia Protein
Proto-Oncogene C-Mpl
Cd Antigen Cd110
Database Links Reactome: R-HSA-76009
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Golgi Apparatus
Cell Surface
Alternative Protein Names Thrombopoietin Receptor protein
Tpo-R protein
Myeloproliferative Leukemia Protein protein
Proto-Oncogene C-Mpl protein
Cd Antigen Cd110 protein
MPL protein
TPOR protein

Information sourced from Uniprot.org

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