| Post Translational Modifications | Ubiquitinated.which may lead to proteasomal degradation. Sumoylation inhibits its ubiquitination and promotes its negative regulation of the CLOCK-BMAL1 heterodimer transcriptional activator activity. |
| Function | Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-BMAL1|BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity. May be involved in the regulation of chondrocyte differentiation via the cAMP pathway. Represses the transcription of NR0B2 and attentuates the transactivation of NR0B2 by the CLOCK-BMAL1 complex. Drives the circadian rhythm of blood pressure through transcriptional repression of ATP1B1 in the cardiovascular system. |
| Protein Name | Class E Basic Helix-Loop-Helix Protein 40Bhlhe40Class B Basic Helix-Loop-Helix Protein 2Bhlhb2Differentially Expressed In Chondrocytes Protein 1Dec1Enhancer-Of-Split And Hairy-Related Protein 2Sharp-2Stimulated By Retinoic Acid Gene 13 Protein |
| Database Links | Reactome: R-HSA-1368108 |
| Cellular Localisation | CytoplasmNucleusPredominantly Localized In The Nucleus |
| Alternative Protein Names | Class E Basic Helix-Loop-Helix Protein 40 proteinBhlhe40 proteinClass B Basic Helix-Loop-Helix Protein 2 proteinBhlhb2 proteinDifferentially Expressed In Chondrocytes Protein 1 proteinDec1 proteinEnhancer-Of-Split And Hairy-Related Protein 2 proteinSharp-2 proteinStimulated By Retinoic Acid Gene 13 Protein proteinBHLHE40 proteinBHLHB2 proteinDEC1 proteinSHARP2 proteinSTRA13 protein |
Information sourced from Uniprot.org
