| Post Translational Modifications | Phosphorylated on tyrosine residues. |
| Function | Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers. Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis. Promotes insulin-mediated membrane ruffling. In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1. Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity. May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction. Regulates EGF-induced DNA synthesis. Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling. Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA. Positively regulates integrin-induced tyrosine phosphorylation of BCAR1. Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS. However, in a contrasting study, lacks GEF activity towards RAP1. |
| Protein Name | Breast Cancer Anti-Estrogen Resistance Protein 3Novel Sh2-Containing Protein 2Sh2 Domain-Containing Protein 3b |
| Cellular Localisation | CytoplasmCell JunctionFocal AdhesionLocalization To Focal Adhesions Depends On Interaction With Ptpra |
| Alternative Protein Names | Breast Cancer Anti-Estrogen Resistance Protein 3 proteinNovel Sh2-Containing Protein 2 proteinSh2 Domain-Containing Protein 3b proteinBCAR3 proteinNSP2 proteinSH2D3B proteinUNQ271 proteinPRO308 protein |
Information sourced from Uniprot.org
