Human AZIN2 protein (Recombinant) (N-His) (STJP006347)

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STJP006347
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human AZIN2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: AZIN2
Gene ID: 113451
Uniprot ID: AZIN2_HUMAN
Immunogen Region: Met1-Glu348
Immunogen: Homo sapiens (Human)
Post Translational Modifications Ubiquitinated, leading to its proteasomal degradation.a process that is reduced in presence of antizymes. May also be degraded through the lysosomal degradative pathway in a proteasomal-independent manner.
Function Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production. Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking.
Protein Name Antizyme Inhibitor 2
Azi2
Arginine Decarboxylase
Adc
Argdc
Ornithine Decarboxylase-Like Protein
Odc-Like Protein
Ornithine Decarboxylase Paralog
Odc-P
Database Links Reactome: R-HSA-351143
Cellular Localisation Nucleus
Cytoplasm
Perinuclear Region
Membrane
Cytoplasmic Vesicle
Endoplasmic Reticulum-Golgi Intermediate Compartment
Golgi Apparatus
Cis-Golgi Network
Trans-Golgi Network
Cytoplasmic Granule
Cell Projection
Axon
Dendrite
Perikaryon
Colocalizes With Kdel Receptors In Er-Golgi Intermediate Compartment (Ergic)
Translocates From The Ergic Structure To The Cytoplasm In An Antizyme-Dependent Manner
Localizes With Vesicle-Associated Membrane Protein Vamp8 In The Vicinity Of The Plasma Membrane Within Serotonin-Containing Secretory Granules
Detected As Vesicle-Like Pattern In Neurite Outgrowths
Localizes To The Vesicular Compartments Of The Secretory Pathway
Predominantly In The Trans-Golgi Network (Tgn)
Alternative Protein Names Antizyme Inhibitor 2 protein
Azi2 protein
Arginine Decarboxylase protein
Adc protein
Argdc protein
Ornithine Decarboxylase-Like Protein protein
Odc-Like Protein protein
Ornithine Decarboxylase Paralog protein
Odc-P protein
AZIN2 protein
ADC protein
KIAA1945 protein
ODCP protein

Information sourced from Uniprot.org