Post Translational Modifications | Ubiquitinated, leading to its proteasomal degradation.a process that is reduced in presence of antizymes. May also be degraded through the lysosomal degradative pathway in a proteasomal-independent manner. |
Function | Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production. Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking. |
Protein Name | Antizyme Inhibitor 2Azi2Arginine DecarboxylaseAdcArgdcOrnithine Decarboxylase-Like ProteinOdc-Like ProteinOrnithine Decarboxylase ParalogOdc-P |
Database Links | Reactome: R-HSA-351143 |
Cellular Localisation | NucleusCytoplasmPerinuclear RegionMembraneCytoplasmic VesicleEndoplasmic Reticulum-Golgi Intermediate CompartmentGolgi ApparatusCis-Golgi NetworkTrans-Golgi NetworkCytoplasmic GranuleCell ProjectionAxonDendritePerikaryonColocalizes With Kdel Receptors In Er-Golgi Intermediate Compartment (Ergic)Translocates From The Ergic Structure To The Cytoplasm In An Antizyme-Dependent MannerLocalizes With Vesicle-Associated Membrane Protein Vamp8 In The Vicinity Of The Plasma Membrane Within Serotonin-Containing Secretory GranulesDetected As Vesicle-Like Pattern In Neurite OutgrowthsLocalizes To The Vesicular Compartments Of The Secretory PathwayPredominantly In The Trans-Golgi Network (Tgn) |
Alternative Protein Names | Antizyme Inhibitor 2 proteinAzi2 proteinArginine Decarboxylase proteinAdc proteinArgdc proteinOrnithine Decarboxylase-Like Protein proteinOdc-Like Protein proteinOrnithine Decarboxylase Paralog proteinOdc-P proteinAZIN2 proteinADC proteinKIAA1945 proteinODCP protein |
Information sourced from Uniprot.org