| Function | Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Essential for the proper assembly and activity of V-ATPase. In renal intercalated cells, mediates secretion of protons (H+) into the urine thereby ensuring correct urinary acidification. Required for optimal olfactory function by mediating the acidification of the nasal olfactory epithelium. |
| Protein Name | V-Type Proton Atpase Subunit B - Kidney IsoformV-Atpase Subunit B 1Endomembrane Proton Pump 58 Kda SubunitVacuolar Proton Pump Subunit B 1 |
| Database Links | Reactome: R-HSA-1222556Reactome: R-HSA-77387Reactome: R-HSA-917977Reactome: R-HSA-9639288Reactome: R-HSA-983712 |
| Cellular Localisation | Apical Cell MembraneBasolateral Cell Membrane |
| Alternative Protein Names | V-Type Proton Atpase Subunit B - Kidney Isoform proteinV-Atpase Subunit B 1 proteinEndomembrane Proton Pump 58 Kda Subunit proteinVacuolar Proton Pump Subunit B 1 proteinATP6V1B1 proteinATP6B1 proteinVATB proteinVPP3 protein |
Information sourced from Uniprot.org
