| Post Translational Modifications | Nitrated under oxidative stress. Nitration on the two tyrosine residues inhibits catalytic activity. Serotonylated on Gln residues by TGM2 in response to hypoxia, leading to its inactivation. |
| Function | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation. Also modulates ER contacts with lipid droplets, mitochondria and endosomes. In coordination with FLVCR2 mediates heme-stimulated switching from mitochondrial ATP synthesis to thermogenesis. Isoform 2: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation. |
| Protein Name | Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 2Serca2Sr Ca(2+-Atpase 2Calcium Pump 2Calcium-Transporting Atpase Sarcoplasmic Reticulum Type - Slow Twitch Skeletal Muscle IsoformEndoplasmic Reticulum Class 1/2 Ca(2+ Atpase |
| Database Links | Reactome: R-HSA-1912420Reactome: R-HSA-418359Reactome: R-HSA-5578775Reactome: R-HSA-936837 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinSarcoplasmic Reticulum MembraneColocalizes With Flvcr2 At The Mitochondrial-Er Contact Junction |
| Alternative Protein Names | Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 2 proteinSerca2 proteinSr Ca(2+-Atpase 2 proteinCalcium Pump 2 proteinCalcium-Transporting Atpase Sarcoplasmic Reticulum Type - Slow Twitch Skeletal Muscle Isoform proteinEndoplasmic Reticulum Class 1/2 Ca(2+ Atpase proteinATP2A2 proteinATP2B protein |
Information sourced from Uniprot.org
