Human ANO6 protein (Recombinant) (N-His) (STJP005538)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ANO6-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ANO6 |
| Gene ID | 196527 |
| Uniprot ID | ANO6_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ala744-Asn824 |
Additional Info
| Function | Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity.scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes. (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, is activated by spike protein which increases the amplitude of spontaneous Ca(2+) signals and is required for spike-mediated syncytia. |
| Protein Name | Anoctamin-6Small-Conductance Calcium-Activated Nonselective Cation ChannelScan ChannelTransmembrane Protein 16f |
| Database Links | Reactome: R-HSA-2672351Reactome: R-HSA-6798695Reactome: R-HSA-9733458 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinShows An Intracellular Localization |
| Alternative Protein Names | Anoctamin-6 proteinSmall-Conductance Calcium-Activated Nonselective Cation Channel proteinScan Channel proteinTransmembrane Protein 16f proteinANO6 proteinTMEM16F protein |
Information sourced from Uniprot.org