Human ANO6 protein (Recombinant) (N-His) (STJP005538)

SKU:
STJP005538
£328.50 - £1,437.50
Free Shipping
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ANO6-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ANO6
Gene ID: 196527
Uniprot ID: ANO6_HUMAN
Immunogen Region: Ala744-Asn824
Immunogen: Homo sapiens (Human)
Function Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity.scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes. (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, is activated by spike protein which increases the amplitude of spontaneous Ca(2+) signals and is required for spike-mediated syncytia.
Protein Name Anoctamin-6
Small-Conductance Calcium-Activated Nonselective Cation Channel
Scan Channel
Transmembrane Protein 16f
Database Links Reactome: R-HSA-2672351
Reactome: R-HSA-6798695
Reactome: R-HSA-9733458
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Shows An Intracellular Localization
Alternative Protein Names Anoctamin-6 protein
Small-Conductance Calcium-Activated Nonselective Cation Channel protein
Scan Channel protein
Transmembrane Protein 16f protein
ANO6 protein
TMEM16F protein

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJP005172 Human COL10A1, N-His protein (Recombinant) (N-His) (STJP005172) E. coli
STJP004723 Human WAS protein (Recombinant) (N-His) (STJP004723) E. coli
STJP008101 Human ARL2BP protein (Recombinant) (N-His) (STJP008101) E. coli
STJP008131 Human SNRPB2 protein (Recombinant) (N-His) (STJP008131) E. coli
STJP008130 Human SMARCD1 protein (Recombinant) (N-His) (STJP008130) E. coli

Related Products

!