Function | Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively. High specificity for all-trans-retinal as substrate, can also accept acetaldehyde as substrate in vitro but with lower affinity. Required for the biosynthesis of normal levels of retinoate in the embryonic ocular and nasal regions.a critical lipid in the embryonic development of the eye and the nasal region. |
Protein Name | Retinaldehyde Dehydrogenase 3Raldh-3Raldh3Aldehyde Dehydrogenase 6Aldehyde Dehydrogenase Family 1 Member A3Aldh1a3 |
Database Links | Reactome: R-HSA-5365859 |
Cellular Localisation | Cytoplasm |
Alternative Protein Names | Retinaldehyde Dehydrogenase 3 proteinRaldh-3 proteinRaldh3 proteinAldehyde Dehydrogenase 6 proteinAldehyde Dehydrogenase Family 1 Member A3 proteinAldh1a3 proteinALDH1A3 proteinALDH6 protein |
Information sourced from Uniprot.org