Anti-PP2A-B55-Beta antibody (STJ95192)


Current Stock:
Host: Rabbit
Applications: WB, ELISA
Reactivity: Human, Mouse, Rat
Short Description: Rabbit polyclonal anti-PP2A-B55-Beta antibody is suitable for use in Western Blot and ELISA.
Clonality: Polyclonal
Conjugation: Unconjugated
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using a epitope-specific immunogen.
Storage Instruction: Store at-20°C, and avoid repeat freeze-thaw cycles.
Concentration: 1 mg/ml
Isotype: IgG
Dilution Range: WB 1:500-1:2000
ELISA 1:40000
Specificity: PP2A-B55-beta polyclonal antibody detects endogenous levels of PP2A-B55-beta protein.
Uniprot ID: 2ABB_HUMAN
Gene ID: 5521
Gene Symbol: PPP2R2B
Immunogen: Synthesized peptide derived from human PP2A-B55-beta
Immunogen Region: 90-170 aa, Internal
Function The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity. Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance.
Protein Name Serine/Threonine-Protein Phosphatase 2a 55 Kda Regulatory Subunit B Beta Isoform
Pp2a Subunit B Isoform B55-Beta
Pp2a Subunit B Isoform Pr55-Beta
Pp2a Subunit B Isoform R2-Beta
Pp2a Subunit B Isoform Beta
Cellular Localisation Isoform 1: Cytoplasm
Isoform 2: Cytoplasm
Mitochondrion Outer Membrane
Under Basal Conditions
Localizes To Both Cytosolic And Mitochondrial Compartments
Relocalizes From The Cytosolic To The Mitochondrial Compartment During Apoptosis
Its Targeting To The Outer Mitochondrial Membrane (Omm) Involves An Association With Import Receptors Of The Tom Complex And Is Required To Promote Proapoptotic Activity
Alternative Antibody Names Anti-Serine/Threonine-Protein Phosphatase 2a 55 Kda Regulatory Subunit B Beta Isoform antibody
Anti-Pp2a Subunit B Isoform B55-Beta antibody
Anti-Pp2a Subunit B Isoform Pr55-Beta antibody
Anti-Pp2a Subunit B Isoform R2-Beta antibody
Anti-Pp2a Subunit B Isoform Beta antibody
Anti-PPP2R2B antibody

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